Irinotecan and temozolomide in combination with dasatinib and rapamycin versus irinotecan and temozolomide for patients with relapsed or refractory neuroblastoma (RIST-rNB-2011): a multicentre, open-label, randomised, controlled, phase 2 trial.
Corbacioglu S, Lode H, Ellinger S, Zeman F, Suttorp M, Escherich G, Bochennek K, Gruhn B, Lang P, Rohde M, Debatin KM, Steinbach D, Beilken A, Ladenstein R, Spachtholz R, Heiss P, Hellwig D, Tröger A, Koller M, Menhart K, Riemenschneider MJ, Zoubaa S, Kietz S, Jakob M, Sommer G, Heise T, Hundsdörfer P, Kühnle I, Dilloo D, Schönberger S, Schwabe G, von Luettichau I, Graf N, Schlegel PG, Frühwald M, Jorch N, Paulussen M, Schneider DT, Metzler M, Leipold A, Nathrath M, Imschweiler T, Christiansen H, Schmid I, Crazzolara R, Niktoreh N, Cario G, Faber J, Demmert M, Babor F, Fröhlich B, Bielack S, Bernig T, Greil J, Eggert A, Simon T, Foell J. Lancet Oncol. 2024 Jul;25(7):922-932. doi: 10.1016/S1470-2045(24)00202-X. PMID: 38936379
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, Alonso MM, Antonelli M, Bailey S, Baugh JN, Biassoni V, Blattner-Johnson M, Broniscer A, Carai A, Colafati GS, Colditz N, Corbacioglu S, Crampsie S, Entz-Werle N, Eyrich M, Friker LL, Frühwald MC, Garrè ML, Gerber NU, Giangaspero F, Gil-da-Costa MJ, Graf N, Hargrave D, Hauser P, Herrlinger U, Hoffmann M, Hulleman E, Izquierdo E, Jacobs S, Karremann M, Kattamis A, Kebudi R, Kortmann RD, Kwiecien R, Massimino M, Mastronuzzi A, Miele E, Morana G, Noack CM, Pentikainen V, Perwein T, Pfister SM, Pietsch T, Roka K, Rossi S, Rutkowski S, Schiavello E, Seidel C, Štěrba J, Sturm D, Sumerauer D, Tacke A, Temelso S, Valentini C, van Vuurden D, Varlet P, Veldhuijzen van Zanten SEM, Vinci M, von Bueren AO, Warmuth-Metz M, Wesseling P, Wiese M, Wolff JEA, Zamecnik J, Morales La Madrid A, Bison B, Gielen GH, Jones DTW, Jones C, Kramm CM. Neuro Oncol. 2024 Sep 5;26(9):1723-1737. doi: 10.1093/neuonc/noae080. PMID: 38717379
Bridging molecular advancements and clinical challenges in pediatric oncology.
Kuhlen M, Frühwald MC. World J Pediatr. 2024 Dec 19. doi: 10.1007/s12519-024-00870-7. Online ahead of print. PMID: 39695048
Platform trials for rare cancers-A complex innovation to accelerate knowledge.
Hau P, Frühwald MC. Neurooncol Pract. 2024 May 24;11(4):365-366. doi: 10.1093/nop/npae035. eCollection 2024 Aug. PMID: 39006529
SWI/SNF-deficient tumors of the central nervous system: An update.
Hasselblatt M, Kool M, Frühwald MC. Clin Neuropathol. 2024 Jan-Feb;43(1):2-9. doi: 10.5414/NP301594. PMID: 37969088
TRIM28 inactivation in epithelial nephroblastoma is frequent and often associated with predisposing TRIM28 germline variants.
Wegert J, Fischer AK, Palhazi B, Treger TD, Hilgers C, Ziegler B, Jung H, Jüttner E, Waha A, Fuchs J, Warmann SW, Frühwald MC, Hubertus J, Pritchard-Jones K, Graf N, Behjati S, Furtwängler R, Gessler M, Vokuhl C. J Pathol. 2024 Jan;262(1):10-21. doi: 10.1002/path.6206. Epub 2023 Oct 4. PMID: 37792584
Spontaneous remission and loss of monosomy 7: a window of opportunity for young children with SAMD9L syndrome.
Erlacher M, Andresen F, Sukova M, Stary J, De Moerloose B, Bosch JVWT, Dworzak M, Seidel MG, Polychronopoulou S, Beier R, Kratz CP, Nathrath M, Frühwald MC, Göhring G, Bergmann AK, Mayerhofer C, Lebrecht D, Ramamoorthy S, Yoshimi A, Strahm B, Wlodarski MW, Niemeyer CM. Haematologica. 2024 Feb 1;109(2):422-430. doi: 10.3324/haematol.2023.283591. PMID: 37584291
Radiation Therapy Plays an Important Role in the Treatment of Atypical Teratoid/Rhabdoid Tumors: Analysis of the EU-RHAB Cohorts and Their Precursors.
Frisch S, Libuschewski H, Peters S, Gerß J, von Hoff K, Kortmann RD, Nemes K, Rutkowski S, Hasselblatt M, Pietsch T, Frühwald MC, Timmermann B. Int J Radiat Oncol Biol Phys. 2024 Jul 15;119(4):1147-1157. doi: 10.1016/j.ijrobp.2024.01.200. Epub 2024 Jan 19. PMID: 38246248
Survivors of infant atypical teratoid/rhabdoid tumors present with severely impaired cognitive functions especially for fluid intelligence and visual processing: data from the German brain tumor studies.
Traunwieser T, Loos E, Ottensmeier H, Gastberger K, Nemes K, Mynarek M, Bison B, Kandels D, Neumayer P, Neumann-Holbeck A, Lüttich P, Baust K, Faulstich-Ritter K, John R, Kreisch A, Landmann J, Manteufel E, Nest A, Prüfe J, Schubert L, Stamm W, Timmermann B, Gerss J, Rutkowski S, Schlegel PG, Eyrich M, Gnekow AK, Frühwald MC. Pediatr Blood Cancer. 2024 May;71(5):e30910. doi: 10.1002/pbc.30910. Epub 2024 Feb 11. PMID: 38342954
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology.
Sturm D, Capper D, Andreiuolo F, Gessi M, Kölsche C, Reinhardt A, Sievers P, Wefers AK, Ebrahimi A, Suwala AK, Gielen GH, Sill M, Schrimpf D, Stichel D, Hovestadt V, Daenekas B, Rode A, Hamelmann S, Previti C, Jäger N, Buchhalter I, Blattner-Johnson M, Jones BC, Warmuth-Metz M, Bison B, Grund K, Sutter C, Hirsch S, Dikow N, Hasselblatt M, Schüller U, Koch A, Gerber NU, White CL, Buntine MK, Kinross K, Algar EM, Hansford JR, Gottardo NG, Schuhmann MU, Thomale UW, Hernáiz Driever P, Gnekow A, Witt O, Müller HL, Calaminus G, Fleischhack G, Kordes U, Mynarek M, Rutkowski S, Frühwald MC, Kramm CM, von Deimling A, Pietsch T, Sahm F, Pfister SM, Jones DTW. Nat Med. 2024 Jan;30(1):306. doi: 10.1038/s41591-023-02652-6. PMID: 37875569
Effectiveness of structured, multidisciplinary long-term care for pediatric cancer survivors: protocol of the multicenter, randomized-controlled AELKI study.
Schmidt H, Baust K, Calaminus G, Hohls L, Tetzner K, Griech N, Haugke H, Baltus H, Elsner S, Katalinic A, Becker H, Cytera C, Gebauer J, Kock-Schoppenhauer AK, Neumann A, Denzer C, Schündeln MM, Faber J, Sattler C, Frühwald MC, Borgmann-Staudt A, Barnbrock A, Metzler M, Escherich G, König IR, Menrath I, Langer T. Trials. 2024 Sep 8;25(1):597. doi: 10.1186/s13063-024-08377-2. PMID: 39245714
Clinical and Molecular Risk Factors in Extracranial Malignant Rhabdoid Tumors: Toward an Integrated Model of High-Risk Tumors.
Fincke VE, Steinbügl M, Chun HE, Nemes K, Mucha M, Loßner M, Dorn F, Gastberger K, Bühner S, Sill M, Kröncke T, Siebert R, Melchior P, Furtwängler R, Schlesner M, Vokuhl C, Röcken C, Johann PD, Frühwald MC. Clin Cancer Res. 2024 Oct 15;30(20):4667-4680. doi: 10.1158/1078-0432.CCR-23-3489. PMID: 39120581
NUT carcinoma in pediatric patients: Characteristics, therapeutic regimens, and outcomes of 11 cases registered with the German Registry for Rare Pediatric Tumors (STEP).
Flaadt T, Wild H, Abele M, Frühwald M, Dirksen U, Classen CF, Seitz C, Redlich A, Lauer UM, Kloker L, Kratz C, Schneider DT, Brecht IB. Pediatr Blood Cancer. 2024 Mar;71(3):e30821. doi: 10.1002/pbc.30821. Epub 2023 Dec 26. PMID: 38148490
Human-Level Differentiation of Medulloblastoma from Pilocytic Astrocytoma: A Real-World Multicenter Pilot Study.
Wiestler B, Bison B, Behrens L, Tüchert S, Metz M, Griessmair M, Jakob M, Schlegel PG, Binder V, von Luettichau I, Metzler M, Johann P, Hau P, Frühwald M. Cancers (Basel). 2024 Apr 11;16(8):1474. doi: 10.3390/cancers16081474. PMID: 38672556
Non-Syndromic and Syndromic Defects in Children with Extracranial Germ Cell Tumors: Data of 2610 Children Registered with the German MAKEI 96/MAHO 98 Registry Compared to the General Population.
Schultewolter JH, Rissmann A, von Schweinitz D, Frühwald M, Blattmann C, Fischer L, Lange BS, Wessalowski R, Fröhlich B, Behnisch W, Schmid I, Reinhard H, Dürken M, Hundsdörfer P, Heimbrodt M, Vokuhl C, Schönberger S, Schneider DT, Seitz G, Looijenga L, Göbel U, von Kries R, Reutter H, Calaminus G. Cancers (Basel). 2024 Jun 6;16(11):2157. doi: 10.3390/cancers16112157. PMID: 38893276
Adaption of neurosurgical resection patterns for pediatric low-grade glioma spanning two decades-Report from the German LGG-studies 1996-2018.
Kelety T, Thomale UW, Kandels D, Schuhmann MU, El Damaty A, Krauss J, Frühwald MC, Driever PH, Witt O, Bison B, Warmuth-Metz M, Pietsch T, Schmidt R, Gnekow AK. Cancer Med. 2024 Jun;13(12):e7417. doi: 10.1002/cam4.7417. PMID: 38923198
