Fachärzte

Originalarbeiten

• Velázquez GF, Weller JF, Rubeck A, Arndt T, Schiele S, Mezger M, Lengerke C, Bethge W, Trepel M, Müller G, Christopeit M, Schmid C. Prophylactic and pre-emptive donor lymphocyte infusion in patients with acute myeloid leukemia and myelodysplastic syndrome: validation of current recommendations and proposal of a modified outcome assessment. Haematologica. 2025 Apr 24. doi: 10.3324/haematol.2024.287206. Epub ahead of print. PMID: 40270206.
• Sauerer, T.*, Velázquez, G.F.* & Schmid, C. Relapse of acute myeloid leukemia after allogeneic stem cell transplantation: immune escape mechanisms and current implications for therapy. Mol Cancer 22, 180 (2023). https://doi.org/10.1186/s12943-023-01889-6
• Filippini Velázquez G, Labopin M, Tischer J, Raiola A, Angelucci E, Kulagin AD, Galieni P, Bermúdez A, Bulabois C, Kröger N, Díez-Martin J, Kwon M, Nagler A, Schmid C, Ciceri F, Mohty M. Second haploidentical stem cell transplantation (HAPLO-SCT2) after relapse from a first HAPLO-SCT in acute leukemia - a study on behalf of the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). Bone Marrow Transplant. 2023
• Filippini Velázquez G, Schiele S, Gerken M, Neumaier S, Hackl C, Mayr P, Klinkhammer-Schalke M, Illerhaus G, Schlitt HJ, Anthuber M, Kröncke T, Messmann H, Märkl B, Schmid C, Trepel M, Müller G, Claus R, Hackanson B. Predictive preoperative clinical score for patients with liver-only oligometastatic colorectal cancer. ESMO Open. 2022 Jun;7(3):100470. doi: 10.1016/j.esmoop.2022.100470. Epub 2022 Apr 20. PMID: 35461024; PMCID: PMC9271475.
• Reese J, Velazquez GF, Weckenbrock J, Kolb G. Behandlung einer sekundären akuten myeloischen Leukämie mit Azacitidin: Erhalt von Lebensqualität und Selbstständigkeit im fortgeschrittenen Lebensalter [Treatment of secondary acute myeloid leukemia with azacitidine: Maintenance of quality of life and independence in advanced age]. Z Gerontol Geriatr. 2020 Jul;53(4):362-364. German. doi: 10.1007/s00391-020-01729-y. Epub 2020 Apr 30. PMID: 32355997.
• Mayr P, Grünewald T, Filippini Velazquez G, Rank A, Schmid C, Harloff M, Märkl B, Trepel M, Hirschbühl K, Pfeiffer T, Claus R. Transfusion-refractory pancytopenia with MDS-like morphologic alterations of the bone marrow in a 29-year old man: A mimicry manifestation caused by scurvy. Br J Haematol. 2022 Jun;197(5):627-630. doi: 10.1111/bjh.18064. Epub 2022 Feb 6. PMID: 35128629.
• Unterfrauner M, Rejeski HA, Hartz A, Bohlscheid S, Baudrexler T, Feng X, Rackl E, Li L, Rank A, Filippini Velázquez G, Schmid C, Schmohl J, Bojko P, Schmetzer H. Granulocyte-Macrophage-Colony-Stimulating-Factor Combined with Prostaglandin E1 Create Dendritic Cells of Leukemic Origin from AML Patients' Whole Blood and Whole Bone Marrow That Mediate Antileukemic Processes after Mixed Lymphocyte Culture. Int J Mol Sci. 2023 Dec 13;24(24):17436. doi: 10.3390/ijms242417436. PMID: 38139264; PMCID: PMC10743754.
• Shumilov E, Wurm-Kuczera R, Kerkhoff A, Wang M, Melchardt T, Holtick U, Bacher U, Staber PB, Mazzeo P, Leng C, Böckle D, Hölscher AS, Kauer J, Rotter N, Vucinic V, Rudzki JD, Nachbaur D, Bücklein VL, Schnetzke U, Krämer I, Wille K, Hasse A, von Tresckow B, Hänel M, Koenecke C, Velazquez GF, Viardot A, Schmid C, Thurner L, Wolf D, Subklewe M, Dreyling M, Dreger P, Dietrich S, Keller U, Jaeger U, Greil R, Pabst T, Lenz G, Chapuy B. Safety and Efficacy of Glofitamab for Relapsed/Refractory Large B-Cell Lymphoma in a Multinational Real-World Study. Blood Adv. 2024 Dec 11:bloodadvances.2024014903. doi: 10.1182/bloodadvances.2024014903. Epub ahead of print. PMID: 39661985.
• Shumilov E, Scholz JK, Seib M, Mazzeo P, Wurm-Kuczera R, Vucinic V, Holtick U, Boyadzhiev H, Melchardt T, Hölscher AS, Schultze-Florey CR, Abdelhafez A, Velazquez GF, Ossami Saidy A, Lesan V, Schnetzke U, Kerkhoff A, Bacher U, Ghandili S, Aydilek E, Gebauer N, Weber T, Wulf GG, Glass B, Thurner L, Heidel FH, Schmid C, Viardot A, Hänel M, Dietrich S, Pabst T, Ayuk FA, von Tresckow B, Chapuy B, Pott C, Müller F, Lenz G. Outcomes of bispecific antibody therapy after CAR T-cell failure in relapsed/refractory large B-cell lymphoma. Blood Adv. 2025 Apr 16:bloodadvances.2024015719. doi: 10.1182/bloodadvances.2024015719. Epub ahead of print. PMID: 40238938.

Conference abstracts (first author)

• Filippini Velazquez G; Aslan, H; Baudrexler, T; Schmetzer, H; Schmid, C. P475: Control leukemia by inducing anti-cancer immune reactivity in vivo? Potential of a DC-triggered mechanism. HemaSphere 6:S3 p 721-722, June 2022. doi: 10.1097/01.HS9.0000852292.38263.b8.
• Bohlscheid, S.,*; Filippini Velazquez*, G.; Aslan, H.; Baudrexler, T.; Schmetzer, H.; Schmid, C. P1309: Dysregulated expressions of inhibitory checkpoint molecules and their ligands on T-cells and blasts in AML relapses after stem cell transplantation (SCT) HemaSphere 6:S3:p 1194-1195, June 2022. doi: 10.1097/01.HS9.0000848100.61250.11.
• Xiaojia Feng*, Giuliano Filippini Velázquez*, Sophia Bohlscheid, Christoph Schmid, Helga Schmetzer. P022: Potential modification of dysregulated expressions of inhibitory checkpoint (ICM) and their ligands on T cells and Blasts in AML relapses after stem cell transplantation (SCT). The 49^th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session (P001-P708). Bone Marrow Transplant 58 (Suppl 1), 153–627 (2023). https://doi.org/10.1038/s41409-023-02056-7
• Giuliano Filippini Velázquez, Jacques-Emmanuel Galimard, Alexandros Spyridonidis, Jakob Passweg, Didier Blaise, Nikolaus Kröger, Igor Wolfgang Blau, Patrice Chevallier, Tobias Gedde-Dahl, Panagiotis Kottaridis, Johan Maertens, Emma Nicholson, Arancha Bermudez Rodriguez, Peter Dreger, Gerald G. Wulf, Mareike Verbeek, Emanuele Angelucci, Mathias Eder, Uwe Platzbecker, Bipin Savani, Christoph Schmid, Fabio Ciceri, Mohamad Mohty. Evaluation of the Transplant Conditioning Intensity (TCI) Score for second allogeneic stem cell transplantation (alloSCT2) - a Study on Behalf of the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT). The 50^th Annual Meeting of the European Society for Blood and Marrow Transplantation (2024): Physicians – Poster Session.
• P. Anand*, G. Filippini Velazquez^*, J. Abdulmajid, X. Feng, K. Hirschbuehl, A. Sinha, C. Schmid^*, H. Schmetzer^*. Treatment with blast-modulatory response modifiers induced specific immune responses and led to disease stabilization in a patient with refractory AML after second allogeneic SCT. The 50^th Annual Meeting of the European Society for Blood and Marrow Transplantation (2024): Physicians – ePoster Session.
• G. Filippini Velazquez et al., EXTRAMEDULLARY RELAPSE OF AML AFTER ALLOGENEIC STEM CELL TRANSPLANTATION: CLINICAL MANIFESTATIONS, TREATMENT MODALITIES AND OUTCOME. Abstract PB2514 (ePoster). EHA Annual Meeting (Madrid 2024)
• G. Filippini Velázquez et al. Digital spatial profiling (DSP) for the assessment of molecular mechanisms involved in extramedullary relapse of acute myeloid leukaemia (eAML) after allogeneic stem cell transplantation. Abstract 163 (Poster). Annual Meeting of the German, Austrian, and Swiss Societies for Hematology and Oncology (Basel 2024)
• G. Filippini Velazquez et al. SECOND ALLOGENEIC SCT (ALLOSCT2) FOR AML IN ACTIVE DISEASE: FEASIBILITY, OUTCOME, AND RISK FACTORS - A STUDY ON BEHALF OF THE ALWP OF THE EBMT – Abstract 1270. Accepted for oral presentation at the 51^th Annual Meeting of the European Society for Blood and Marrow Transplantation (Florence, 2025)
• G. Filippini Velazquez et al. ANALYSIS OF CHARACTERISTICS, OUTCOME AND RISK FACTORS OF PATIENTS WITH MDS UNDERGOING A SECOND ALLOGENEIC SCT (ALLOSCT2) – A STUDY ON BEHALF OF THE CMWP. Abstract 1530. Accepted for oral presentation at the 51^th Annual Meeting of the European Society for Blood and Marrow Transplantation (Florence, 2025)

Awards and Grants:

• Clinical Research Training in Hematology (CRTH) – EHA 2024 edition
• Master Class EHA 2024/2025 edition
• WERA Publication award 2023

Originalarbeiten

• Hoelsch K, Lenggeler I, Pfannes W, Knabe H, Klein HG, Woelpl A: Routine HLA-B genotyping with PCR-sequence-specific oligonucleotides detects a B*52 variant (B*5206). Tissue Antigens. 2005 May;65(5):488-92. PMID: 15853905

• Holler E, Ertl B, Hintermeier-Knabe R, Roncarolo MG, Eissner G, Mayer F, Fraunberger P, Behrends U, Pfannes W, Kolb HJ, Wilmanns W: Inflammatory reactions induced by pretransplant conditioning--an alternative target for modulation of acute GvHD and complications following allogeneic bone marrow transplantation? Leuk Lymphoma. 1997 Apr;25(3-4):217-24. Review.PMID: 9168432

Abstracts

• Pfannes W, Rustige E, Albiez M, Schreglmann M, Isaza A, Ertl B, Kolb HJ, Holler E: Intracytoplasmatic cytokine detection: aGvHD-dependent induction of tumornecrosisfactor alpha and interleukin 1 beta after allogenic BMT European Cytokine Netw, 1996, Apr – Jun, 7(2), 270

Übersichtsartikel

• Claus R., Pfannes W: Neuer Blickwinkel auf die Biologie des IGHV-Mutationsstatus bei der CLL. Karger Kompass Onkol 2019;6:102-103

Originalarbeiten

• Lutz S, D'angelo A, Hammerl S, Schmutz M, Claus R, Fischer N, Kramer F, Hammoud Z, Unveiling the Digital Evolution of Molecular Tumor Boards, https://doi.org/10.1007/s11523-024-01109-1

• Kuhlen M, Schaller T, Dintner S, Stadler N, Hofmann TG, Schmutz M, Claus R, Frühwald MC, Golas MM. Double Heterozygous Pathogenic Variants in TP53 and CHEK2 in Boy with Undifferentiated Embryonal Sarcoma of the Liver. International Journal of Molecular Sciences. October 2024.

• Markus Krebs, Florian Haller, Silvia Spörl, Elena Gerhard-Hartmann, Kirsten Utpatel, Katja Maurus, Volker Kunzmann, Manik Chatterjee, Vivek Venkataramani, Imad Maatouk, Max Bittrich, Tatjana Einwag, Norbert Meidenbauer, Lars Tögel, Daniela Hirsch, Wolfgang Dietmaier, Felix Keil, Alexander Scheiter, Alexander Immel, Daniel Heudobler, Sabine Einhell, Ulrich Kaiser, Anja M. Sedlmeier, Julia Maurer, Gerhard Schenkirsch, Frank Jordan, Maximilian Schmutz, Sebastian Dintner, Andreas Rosenwald, Arndt Hartmann, Matthias Evert, Bruno Märkl, Ralf Bargou, Andreas Mackensen, Matthias W. Beckmann, Tobias Pukrop, Wolfgang Herr, Hermann Einsele, Martin Trepel, Maria-Elisabeth Goebeler, Rainer Claus, Alexander Kerscher, Florian Lüke. The WERA Cancer Center Matrix: Strategic Management of Patient Access to Precision Oncology in a Large and Mostly Rural Area of Germany, European Journal of Cancer. May 2024

• Sebastian Sommer*, Maximilian Schmutz*, Kathrin Hildebrand, Annett Schiwitza, Selinah Benedikt, Maria Eberle, Tatiana Mögele, Aziz Sultan, Lena Reichl, Maria Campillo, Luise Uhrmacher, Ana Antic Nikolic, Ralph Bundschuh, Constantin Lapa, Michaela Kuhlen, Sebastian Dintner, Angela Langer, Bruno Märkl, Thomas Wendler, Kartikay Tehlan, Thomas Kröncke, Maria Wahle, Matthias Mann, Nicolas Casadei, Michaela Pogoda, Simone Hummler, Irmengard Sax, Matthias Schlesner, Boris Kubuschok, Martin Trepel1, Rainer Claus - Concept and feasibility of the Augsburg Longitudinal Plasma Study (ALPS) - A prospective trial for comprehensive liquid biopsy-based longitudinal monitoring of solid cancer patients, Journal of Laboratory Medicine, April 2024 - (* shared first authorship with equal contribution)

• Dintner S, Schmutz M, Sommer S, Langer A, Hirschbühl K, Claus R, Schmid C, Trepel M, Märkl B, NGS-based molecular genetics of leukemia – a powerful and decentralized approach. Pathologie (Heidelberg). Nov 2023

• Pigat L, Geisler B P, Sheikhalishahi S, Sander J, Kaspar M, Schmutz M, Rohr S O, Wild C M, Goss S, Zaghoudi S, Hinske L C, Predicting Hypoxia Using Machine Learning: Systematic Review. JMIR Med Inform. Nov 202

• Sommer S*, Schmutz M*, Schaller T, Mayr P, Dinter S, Märkl B, Huss R, Golas Monika M, Kuhlen M, Jordan F, Claus R, Heinrich B..Individualized targeted treatment in a case of a rare TFG::ROS1 fusion positive inflammatory myofibroblastic tumor (IMT). Cancer Reports. October 2023, (*shared first authorship with equal contribution)

• Schmutz M, Zucknick M, Schlenk R, Mertens D, Benner A, Weichenhan D, Mücke O, Döhner K, Plass C, Claus R, Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen. Clinical Epigenetics. October 2023

• Mayr P, Lutz M, Schmutz M, Hoeppner J, Liesche-Starnecker F, Schlegel J, Gaedcke J, Claus R, Progressive multifocal leukoencephalopathy associated with chemotherapy induced lymphocytopenia in solid tumors – case report of an underestimated complication. Frontiers in Oncology. August. 2022

• Giacopelli B, Wang M, Cleary A, Wu Y-Z, Reister Schlutz A, Schmutz M, Blachly J, Eisfeld A, Mundy-Bosse B, Vosberg S, Greif P, Claus R, Bullinger L, Garzon R, Coombes K, Bloomfield CD, Druker B, Tyner J, Byrd JC, Oakes C, DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia. Genome Research.Mar 2021

• Schlosser P, Knaus J, Schmutz M, Döhner K, Plass C, Bullinger L, Claus R, Binder H, Lübbert M, Schumacher M.. Netboost: Boosting-supported Network Analysis Improves High-Dimensional Omics Prediction in Acute Myeloid Leukemia and Huntington's Disease. IEEE/ACM Transactions on Computational Biology and Bioinformatics. Accepted, Feb 2020
• Schmutz M, Schaller T, Kubuschok B, Fleischmann C, Hirschbühl K, Dintner S, Häckel T, Märkl B, Trepel M, Claus R.: Periodic fever and pancytopenia in a 35-year-old patient. Internist (Berl). 2019 Sep 23

Übersichtsartikel

• Schmutz M, Claus R, CLL-Therapie im stetigen Wandel: vom molekularen Verständnis hin zu individualisierten Therapiestrategien, Onkologie heute, Mar 2024, ISSN 1612-006X
• Claus R, Schmutz M.: Metastasiertes Pankreaskarzinom: Progression kann durch zielgerichtete Therapie gestoppt werden. Karger Kompass Onkol 2019;6:210-212.
• Schmutz M, Trepel M, Claus R.: Chemotherapie-freie Behandlung der CLL. TumorDiagn u Ther 2019; 40(01): 29-

Buchbeiträge

• DNA methylation abnormalities in hematopoietic disorders. Biological Significance and Methodological Approaches. Epigenetic Therapy of Cancer: Preclinical Models and Treatment Approaches (M. Lübbert, P.A. Jones) Springer Verlag. Berlin Heidelberg 2014: 107-121

Poster und Abstracts

• Schmutz M, Zucknick M, Schlenk R F, Döhner K, Döhner H, Plass C, Bullinger L, Claus R. (Dezember 2013) Differential DNA Methylation Predicts Response To Combined Treatment Regimens With a DNA Methyltransferase Inhibitor in Acute Myeloid Leukemia (AML). Konferenzposter, vorgestellt auf der Jahrestagung der American Society of Hematology (ASH), New Orleans, USA, Blood (2013) 122 (21): 2539