Publikationen Prof. Dr. Martin Trepel - Universitätsklinikum Augsburg

Originalarbeiten

Wei C, Jiang W, Wang R, Zhong H, He H, Gao X, Zhong S, Yu F, Guo Q, Zhang L, Schiffelers LDJ, Zhou B, Trepel M, Schmidt FI, Luo M, Shao F: Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Nature 2024 in press
Schlosser P, Schiwitza A, Klaus J, Hieke-Schulz S, Szic KSV, Duyster J, Trepel M, Zirlik K, Schumacher M, Claus R: Conditional survival to assess prognosis in patients with chronic lymphocytic leukemia. Ann Hematol. in press
Liebich A, Enke JS, Reitsam NG, Trepel M, Wienand G, Bundschuh RA, Pfob CH, Dierks A, Lapa C, Kircher M: SSTR Antagonists as Theranostic Option in Small Cell Lung Cancer. Am J Respir Crit Care Med., in press
Höhne K, Wagenknecht A, Maier C, Engelhard P, Goldmann T, Schließmann SJ, Plönes T, Trepel M, Eibel H, Müller-Quernheim J, Zissel G: Pro-Fibrotic Effects of CCL18 on Human Lung Fibroblasts Are Mediated via CCR6. Cells 13, 238, 2024
Enke JS, Reitsam NG, Grosser B, Kircher M, Dierks A, Bundschuh RA, Wienand G, Uhrmacher L, Trepel M, Schottelius M, Lapa C, Pfob CH: C-X-C Motif Chemokine Receptor 4-Directed Scintigraphy of Multiple Myeloma Using [99mTc]Tc-PentixaTec. J Nucl Med. 65, 163-164, 2024
Grosser B, Emmerson J, Reitsam NG, Cunningham D, Nankivell M, Langley RE, Allum WH, Trepel M, Märkl B, Grabsch HI: Stroma AReactive Invasion Front Areas (SARIFA) improves prognostic risk stratification of perioperative chemotherapy treated oesophagogastric cancer patients from the MAGIC and the ST03 trial. Br J Cancer 130, 457-466, 2023
Enke JS, Gäble A, Reitsam NG, Schaller T, Trepel M, Hirschbühl K, Welzel J, Dierks A, Kircher M, Lapa C: Granulomatous dermatitis: a rare pitfall in lymphoma staging with [18F]FDG-PET/CT. Eur J Nucl Med Mol Imaging 50, 3479-3480, 2023
Dierks A Gäble A, Rinscheid A, Wienand G, Pfob CH, Kircher M, Enke JS, Janzen T, Patt M, Trepel M, Weckermann D, Bundschuh RA, Lapa C: First Safety and Efficacy Data with the Radiohybrid 177Lu-rhPSMA-10.1 for the Treatment of Metastatic Prostate Cancer. J Nucl Med. 123, 266741, 2023
Rinscheid A, Gäble A, Wienand G, Pfob C, Dierks A, Kircher M, Trepel M, Weckermann D, Lapa C, Bundschuh RA.: An Intrapatient Dosimetry Comparison of 177Lu-rhPSMA-10.1 and 177Lu-PSMA-I&T in Patients with Metastatic Castration-Resistant Prostate Cancer. J Nucl Med. 64, 1918-1924, 2023
Illert AL, Stenzinger A, Bitzer M, Horak P, Gaidzik VI, Möller Y, Beha J, Öner Ö, Schmitt F, Laßmann S, Ossowski S, Schaaf CP, Hallek M, Brümmendorf TH, Albers P, Fehm T, Brossart P, Glimm H, Schadendorf D, Bleckmann A, Brandts CH, Esposito I, Mack E, Peters C, Bokemeyer C, Fröhling S, Kindler T, Algül H, Heinemann V, Döhner H, Bargou R, Ellenrieder V, Hillemanns P, Lordick F, Hochhaus A, Beckmann MW, Pukrop T, Trepel M, Sundmacher L, Wesselmann S, Nettekoven G, Kohlhuber F, Heinze O, Budczies J, Werner M, Nikolaou K, Beer AJ, Tabatabai G, Weichert W, Keilholz U, Boerries M, Kohlbacher O, Duyster J, Thimme R, Seufferlein T, Schirmacher P, Malek NP: The German Network for Personalized Medicine to enhance patient care and translational research. Nature Medicine 29, 1298-1301, 2023
Claaß LV, Mayr P, Paschold L, Weber T, Terziev D, Jehs B, Brill R, Dober J, Märkl B, Wickenhauser C, Czapiewski P, Trepel M, Claus R, Binder M: No association of malignant B-cell non-Hodgkin lymphomas with ipsilateral SARS-CoV-2 vaccination. Cancer Med. 12, 9313-9321, 2023
Filippini Velázquez G, Schiele S, Gerken M, Neumaier S, Hackl C, Mayr P, Klinkhammer-Schalke M, Illerhaus G, Schlitt HJ, Anthuber M, Kröncke T, Messmann H, Märkl B, Schmid C, Trepel M, Müller G, Claus R, Hackanson B: Predictive preoperative clinical score for patients with liver-only oligometastatic colorectal cancer. ESMO Open 7, 100470, 2022
Remes A, Körbelin J, Arnold C, Rowedder C, Heckmann M, Mairbäurl H, Frank D, Korff T, Frey N, Trepel M, Müller OJ: Adeno-Associated Virus-Mediated Gene Transfer of Inducible Nitric Oxide Synthase to an Animal Model of Pulmonary Hypertension. Hum Gene Ther 33, 959-967, 2022
Lüke F, Haller F, Utpatel K, Krebs M, Meidenbauer N, Scheiter A, Spoerl S, Heudobler D, Sparrer D, Kaiser U, Keil F, Schubart C, Tögel L, Einhell S, Dietmaier W, Huss R, Dintner S, Sommer S, Jordan F, Goebeler ME, Metz M, Haake D, Scheytt M, Gerhard-Hartmann E, Maurus K, Brändlein S, Rosenwald A, Hartmann A, Märkl B, Einsele H, Mackensen A, Herr W, Kunzmann V, Bargou R, Beckmann MW, Pukrop T, Trepel M, Evert M, Claus R, Kerscher A: Identification of Disparities in Personalized Cancer Care-A Joint Approach of the German WERA Consortium. Cancers 14, 5040, 2022
Jordan F, Trepel M, Claus R: Restoring Immune Mediated Disease C76. Jordan F, Trepel M, Claus R: Restoring Immune Mediated Disease Control by Ipilimumab Re-exposition in a Heavily pretreated Patient With MSI-H mCRC. Clin Colorectal Cancer 21, e148-e151, 2022
Mayr P, Grünewald T, Filippini Velazquez G, Rank A, Schmid C, Harloff M, Märkl B, Trepel M, Hirschbühl K, Pfeiffer T, Claus R: Transfusion-refractory pancytopenia with MDS-like morphologic alterations of the bone marrow in a 29-year old man: A mimicry manifestation caused by scurvy. Br J Haematol 197, 627-630, 2022
Olschewski P, Kaspar-Ott I, Koller S, Schenkirsch G, Trepel M, Hertig E: Associations between Weather, Air Quality and Moderate Extreme Cancer-Related Mortality Events in Augsburg, Southern Germany. Int J Environ Res Public Health 8, 11737, 2021
Staquicini FI, Hajitou A, Driessen WH, Proneth B, Cardó-Vila M, Staquicini DI, Markosian C, Hoh M, Cortez M, Hooda-Nehra A, Jaloudi M, Silva IT, Buttura J, Nunes DN, Dias-Neto E, Eckhardt B, Ruiz-Ramírez J, Dogra P, Wang Z, Cristini V, Trepel M, Anderson R, Sidman RL, Gelovani JG, Cristofanilli M, Hortobagyi GN, Bhujwalla ZM, Burley SK, Arap W, Pasqualini R: Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer. Elife 10, e65145, 2021
Jordan F, Huber S, Sommer S, Schenkirsch G, Frühwald MC, Trepel M, Claus R, Kuhlen M: A Retrospective 5-Year Single Center Study Highlighting the Risk of Cancer Predisposition in Adolescents and Young Adults. Cancers 13, 3033 2021
Alvarez-Vergara MI, Rosales-Nieves AE, March-Diaz R, Rodriguez-Perinan G, Lara-Ureña N, Ortega-de San Luis C, Sanchez-Garcia MA, Martin-Bornez M, Gómez-Gálvez P, Vicente-Munuera P, Fernandez-Gomez B, Marchena MA, Bullones-Bolanos AS, Davila JC, Gonzalez-Martinez R, Trillo-Contreras JL, Sanchez-Hidalgo AC, del Toro R, Scholl FG, Herrera E, Trepel M, Körbelin J, Escudero LM, Villadiego J, Echevarria M, de Castro F, Gutierrez A, Rabano A, Vitorica J, Pascual A: Non-productive angiogenesis disassembles Aß plaque-associated blood vessels. Nature Communications 12, 3098, 202
Waidhauser J, Martin B, Trepel M, Märkl B: Can low autopsy rates be increased? Yes, we can! Should postmortem examinations in oncology be performed? Yes, we should! A postmortem analysis of oncological cases. Virchows Arch. 478, 310-308, 2021
Waidhauser J, Schuh A, Trepel M, Schmälter AK, Rank A: Chemotherapy markedly reduces B cells but not T cells and NK cells in patients with cancer. Cancer Immunol. Immunother 69, 147-157, 2020
Schaller T, Hirschbühl K, Burkhardt K, Braun G, Trepel M, Märkl B, Claus R: Postmortem Examination of Patients With COVID-19. JAMA 323, 2518-2520, 2020
Grundmann N, Meisinger C, Trepel M, Müller-Nordhorn J, Schenkirsch G, Linseisen J: Trends in cancer incidence and survival in the Augsburg study region-results from the Augsburg cancer registry. BMJ Open 10, e036176, 2020
Hirschbuehl K, Rank A, Pfeiffer T, Schaller T, Haeckel T, Roeling J, Vlasenko D, Trepel M, Schmid C: Large Vessel Vasculitis as a Possible Mechanism of Vascular Side Effects of Ponatinib: A Case Report. J. Hematol. 8, 83-85, 2019Hirschbuehl K, Rank A, Pfeiffer T, Schaller T, Haeckel T, Roeling J, Vlasenko D, Trepel M, Schmid C: Large Vessel Vasculitis as a Possible Mechanism of Vascular Side Effects of Ponatinib: A Case Report. J. Hematol. 8, 83-85, 2019
Schmutz M, Schaller T, Kubuschok B, Fleischmann C, Hirschbühl K, Dintner S, Häckel T, Märkl B, Trepel M, Claus R: [Periodic fever and pancytopenia in a 35-year-old patient] Periodisches Fieber und Panzytopenie bei einem 35‑jährigen Patienten. Internist 60, 1305-1310, 2019
Waidhauser J, Bornemann A, Trepel M, Märkl B: Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia. World J. Gastroenterol. 25, 4261-4277, 2019
Gomes de Castro MA, Wildhagen H, Sograte-Idrissi S, Hitzing C, Binder M, Trepel M, Engels N, Opazo F: Differential organization of tonic and chronic B cell antigen receptors in the plasma membrane. Nature Commun. 10, 820, 2019
Eichhoff AM, Börner K, Albrecht B, Schäfer W, Baum N, Haag F, Körbelin J, Trepel M, Braren I, Grimm D, Adriouch S, Koch-Nolte F: Nanobody-Enhanced Targeting of AAV Gene Therapy Vectors. Mol Ther Methods Clin Dev. 15, 211-220, 2019
Jordan F, Grundmann N, Schenkirsch G, Märkl B, Messmann H, Anthuber M, Schmid C, Trepel M: Impact of Primary tumor localization on the efficacy of bevacizumab in metastatic colorectal cancer. Anticancer Res. 38, 5539-5546, 2018
Körbelin J, Hunger A, Alawi M, Sieber T, Binder M, Trepel M: Optimization of design and production strategies for novel adeno-associated viral display peptide libraries. Gene Ther. 24, 470-481, 2017
Dogbevia GK, Töllner K, Körbelin J, Bröer S, Ridder DA, Grasshoff H, Brandt C, Wenzel J, Straub BK, Trepel M, Löscher W, Schwaninger M: Gene Therapy Decreases Seizures in a Model of Incontinentia Pigmenti. Ann Neurol. 82, 93-104, 2017
Braig F, Kriegs M, Voigtlaender M, Habel B, Grob T, Biskup K, Blanchard V, Sack M, Thalhammer A, Ben Batalla I, Braren I, Laban S, Danielczyk A, Goletz S, Jakubowicz E, Märkl B, Trepel M, Knecht R, Riecken K, Fehse B, Loges S, Bokemeyer C, Binder M: Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism. Cancer Res. 77, 1188-1199, 2017
Körbelin J, Trepel M: How to Successfully Screen Random Adeno-Associated Virus Display Peptide Libraries In Vivo. Hum. Gene Ther. Methods 3, 109-123, 2017
56. Fichtner M, Spies E, Seismann H, Riecken K, Engels N, Gösch B, Dierlamm J, Gerull H, Nollau P, Klapper W, Dreyling M, Binder M, Trepel M: Complementarity determining region-independent recognition of a superantigen by B-cell antigen receptors of mantle cell lymphoma. Haematologica 101, e378-381, 2016
Körbelin J, Sieber T, Michelfelder S, Lunding L, Spies E, Hunger A, Alawi M, Rapti K, Indenbirken D, Müller OJ, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M: Pulmonary targeting of adeno-associated viral vectors by NEXT-generation sequencing-guided screening of random capsid displayed peptide libraries. Mol. Ther. 24, 1050-1061, 2016
Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M*, Trepel M: A brain microvasculature endothelial cell-specific viral vector for the treatment of neurovascular and neurological diseases. EMBO Mol. Med. 8, 609-625, 2016
Pilger A, Tsilimparis N, Bockhorn M, Trepel M, Dreimann M: Combined modified en bloc corpectomy with replacement of the aorta in curative interdisciplinary treatment of a large osteosarcoma infiltrating the aorta. Eur. Spine J. 25 Suppl 1, 58-62, 2016
Spies E, Fichtner M, Müller F, Krasemann S, Illerhaus G, Glatzel M, Binder M, Trepel M: Comment on "Primary Central Nervous System (CNS) Lymphoma B Cell Receptors Recognize CNS Proteins". J. Immunol. 195, 4549-4550, 2015
Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F: Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection. Contrast Media Mol. Imaging 10, 367-378, 2015
Trepel M, Körbelin J, Spies E, Heckmann MB, Hunger A, Fehse B, Katus HA, Kleinschmidt JA, Müller OJ, Michelfelder S: Treatment of multifocal breast cancer by systemic delivery of dual-targeted adeno-associated viral vectors. Gene Ther. 22, 840-847, 2015
Voigtlaender M, Vogler B, Trepel M, Panse J, Jung R, Bokemeyer C, Bacher U, Binder M.: Hospital population screening reveals overrepresentation of CD5- monoclonal B-cell lymphocytosis and monoclonal gammopathy of undetermined significance of IgM type. Ann. Hematol. 94, 1559-1565, 2015
Sieber T, Hare E, Hofmann H, Trepel M: Biomathematical description of synthetic peptide libraries. PLoS One 10, e0129200, 2015
Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F: Validation of nanobody and antibody based in vivo tumor xenograft NIRF-imaging experiments in mice using ex vivo flow cytometry and microscopy. J. Vis. Exp., 6, e52462, 2015
Rissiek A, Schulze C, Bacher U, Schieferdecker A, Thiele B, Jacholkowski A, Flammiger A, Horn C, Haag F, Tiegs G, Zirlik K, Trepel M, Tolosa E, Binder M: Multidimensional scaling analysis identifies pathological and prognostically relevant profiles of circulating T-cells in chronic lymphocytic leukemia. Int. J. Cancer 135, 2370-2379, 2014
Thiele B, Kloster M, Alawi M, Indenbirken D, Trepel M, Grundhoff A, Binder M: Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma. Blood 123, 3618-3621, 2014
Tachezy M, Gebauer F, Petersen C, Arnold D, Trepel M, Wegscheider K, Schafhausen P, Bockhorn M, Izbicki JR, Yekebas E: Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893, ISRCTN82191749). BMC Cancer 14, 411, 2014
Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Koch-Nolte F: In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies. Contrast Media Mol Imaging 9, 135-142, 2014
Flammiger, A, Weisbach L, Huland H, Tennstedt P, Simon R, Minner S, Bokemeyer C, Sauter G, Schlomm T, Trepel M: High tissue density of FOXP3+ T cells is associated with clinical outcome in prostate cancer. Eur J Cancer 49, 1273-1279, 2013
Binder M, Müller F, Frick M, Wehr C, Simon F, Leistler B, Veelken H, Mertelsmann R, Trepel M: CLL B cell receptors can recognize themselves: alternative epitopes and structural clues for autostimulatory mechanisms in CLL. Blood 121, 239-241, 2013
Flammiger A, Bayer F, Cirugeda-Kühnert A, Huland H, Tennstedt P, Simon R, Minner S, Bokemeyer C, Sauter G, Schlomm T, Trepel M: Intratumoral T- but not B-lymphocytes are related to clinical outcome in prostate cancer. APMIS 120, 901-908, 2012
Varadi K, Michelfelder S, Korff T, Hecker M, Trepel M, Katus HA, Kleinschmidt JA, Müller OJ: Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors. Gene Ther. 19, 800-809, 2012
Trepel M, Martens V, Doll C, Rahlff J, Gösch B, Loges S, Binder M: Phenotypic Detection of Clonotypic B Cells in Multiple Myeloma by Specific Immunoglobulin Ligands Reveals their Rarity in Multiple Myeloma. PLoS One 7, e31998, 2012.
Naumer M, Ying Y, Michelfelder S, Reuter A, Trepel M, Müller OJ, Kleinschmidt JA: Development and validation of novel AAV2 random libraries displaying peptides of diverse lengths and at diverse capsid positions. Hum Gene Ther. 23, 492-507, 2012
Wehr C, Müller F, Schüler J, Tomann T, Nitschke C, Seismann H, Spillner E, Klingner K, Schneider-Merck T, Binder M, Fiebig HH, Mertelsmann R, Trepel M: Anti-tumor activity of a B-cell receptor-targeted peptide in a novel disseminated lymphoma xenograft model. Int. J. Cancer 131, E10-20, 2012
Müller-Schmah CI, Solari L, Weis R, Pfeifer D, Scheibenbogen C, Trepel M, May AM, Engelhardt R, M Lübbert M: Immune response as a possible mechanism of long-lasting disease control in spontaneous remission of MLL/AF9-positive acute myeloid leukemia. Ann. Hematology 91, 27-32, 2012
Staquicini FI, Cardó-Vila M, Kolonin MG, Trepel M, Edwards JK, Nunes DN, Sergeeva A, Efstathiou E, Sun J, Almeida NF, Tu SM, Botz GH, Wallace MJ, O'Connell DJ, Krajewski S, Gershenwald JE, Molldrem JJ, Flamm AL, Koivunen E, Pentz RD, Dias-Neto E, Setubal JC, Cahill DJ, Troncoso P, Do KA, Logothetis CJ, Sidman RL, Pasqualini R, Arap W: Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc. Natl. Acad. Sci. USA 108, 18637-18642, 2011
Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M: Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo, PLoS One 6, e23101, 2011
Binder M, Müller F, Jackst A, Léchenne B, Pantic M, Bacher U, Eulenburg CZ, Veelken H, Mertelsmann R, Pasqualini R, Arap W, Trepel M: B-cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia. Cancer 117, 1891-1900, 2011
Binder M, Léchenne B, Ummanni R, Scharf C, Balabanov S, Trusch M, Schlüter H, Braren I, Spillner E, Trepel M: Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells. PLoS One 5, e15992, 2010
Kohlschütter J, Michelfelder S, Trepel M: Novel Cytotoxic Vectors Based on Adeno-Associated Virus. Toxins 2, 2754-2768, 2010
Ying Y, Müller OJ, Goehringer C, Leuchs B, Trepel M, Katus HA, Kleinschmidt JA: Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library. Gene Therapy 17, 980-990, 2010
Trepel M, Stoneham CA, Eleftherohorinou H, Mazarakis ND, Pasqualini R, Arap W, Hajitou A: A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer. Mol. Cancer Ther. 8, 2383-2391, 2009
Michelfelder S, Kohlschütter J, Skorupa A, Pfennings S, Müller O, Kleinschmidt JA, Trepel M: Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries. PLoS ONE 4, e5122, 2009
Michelfelder S, Lee M-K, de Lima-Hahn E, Wilmes T, Kaul F, Müller O, Kleinschmidt JA, Trepel M: Vectors selected from adeno-associated viral display peptide libraries for leukemia cell-targeted cytotoxic gene therapy. Exp. Hematol. 35, 1766–1776, 2007
Binder M, Vögtle FN, Michelfelder S, Müller F, Illerhaus G, Sundararajan S, Mertelsmann R, Trepel M: Identification of their epitope reveals the structural basis for the mechanism of action of the immunosuppressive antibodies basiliximab and daclizumab. Cancer Res. 67, 3518-3523, 2007
Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W: Design and construction of targeted AAVP vectors for mammalian cell transduction. Nature Protocols 2, 523-531, 2007
Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani JG, Alauddin MM: Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nature Protocols 2, 416-423, 2007
Jäger S, Jahnke A, Wilmes T, Adebahr S, Vögtle FN, deLima-Hahn E, Pfeifer D, Berg T, Lübbert M, Trepel M: Leukemia targeting ligands isolated from phage display peptide libraries. Leukemia 21, 411-420, 2007
Waterkamp DA, Müller OJ, Ying Y, Trepel M, Kleinschmidt JA: Isolation of targeted AAV2 vectors from novel virus display libraries. J. Gene Med. 8, 1307-1319, 2006
Binder M, Otto F, Mertelsmann R, Veelken H, Trepel M: The epitope recognized by rituximab. Blood 108, 1975-1978, 2006
Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin M, Marini FC, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W: A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell 125, 385-398, 2006
Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R: Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am. J. Pathol. 166, 625-636, 2005
Müller CI, Trepel M, Kunzmann R, Lais A, Engelhardt R, Lübbert M: Hematologic and molecular spontaneous remission following sepsis in acute monoblastic leukemia with translocation (9;11): a case report and review of the literature. Eur. J. Haematol. 73, 62–66, 2004
Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HBPM, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W: Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell 5, 151-162, 2004
Müller OJ*, Kaul F*, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA*, Trepel M*: Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nature Biotechnology 21, 1040-1046, 2003
Tamm I*, Trepel M*, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R: Peptides targeting caspase inhibitors. J. Biol. Chem. 278, 14401-14405, 2003.
Engelhardt M, Jakob A, Rüter B, Trepel M, Hirsch F, Lübbert M: Severe cold hemagglutinin disease (CHD) successfully treated with rituximab. Blood 100, 1922-1923, 2002
Arap W, Kolonin MG*, Trepel M*, Lahdenranta J, Cardo-Vila M, Giordano RJ, , Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R: Steps towards mapping the human vasculature by phage display. Nature Medicine 8, 121-127, 2002
Trepel M, Arap W, Pasqualini R: Modulation of humoral immune response by targeting antigens to lymph nodes. Cancer Research 61, 8110-8112, 2001
Grifman M, Trepel M, Speece P, Gilbert LB, Arap W, Pasqualini R, Weitzman MD: Incorporation of tumor-targeting peptides into recombinant adeno-associated virus (rAAV) capsids. Molecular Therapy 3, 964-975, 2001
Trepel M, Grifman M, Weitzman MD, Pasqualini R: Molecular adaptors for vascular-targeted adenoviral gene delivery. Hum. Gene Therapy 11, 1971-1981, 2000
Trepel M, Groscurth P, Malipiero U, Gulbins E, Dichgans J, Weller M: Chemosensitivity of malignant glioma: modulation by p53 gene transfer. J. Neuro-Oncol. 39, 19-32, 1998
Reber U, Wüllner U, Trepel M, Baumgart J, Seyfried J, Klockgether T, Dichgans J, Weller M: Potentiation of Treosulfan toxicity by the glutathione-depleting agent buthionine sulfoximine in human malignant glioma cells - the role of bcl-2. Biochem. Pharmacol. 55, 349-359, 1998
Trepel M, Scheding S, Groscurth P, Horny HP, Malipiero U, Brugger W, Dichgans J, Weller M: A new look at the role of p53 in leukemia cell sensitivity to chemotherapy. Leukemia 11, 1842-1849, 1997
Weller M, Trepel M, Grimmel C, Schabet M, Bremen D, Krajewski S, Reed JC: Hypericin-induced apoptosis of human malignant glioma cells is light-dependent, independent of bcl-2 expression, and does not require wild-type p53. Neurol. Res. 19, 459-470, 1997
Wagenknecht B, Trepel M, von Deimling A, Grimmel C, Rollbrocker B, Hayashi Y, Lang F, Dichgans J, Gulbins E, Weller M: p53 accumulation promotes dephosphorylation and proteolytic cleavage of retinoblastoma protein in human malignant glioma cells. Cell Physiol. Biochem. 7, 304-311, 1997
Roth W, Fontana A, Trepel M, Reed JC, Dichgans J, Weller M: Immunochemotherapy of malignant glioma: synergistic activity of CD95 ligand and chemotherapeutics. Cancer Immunol. Immunother. 44, 55-63, 1997
Trepel M, Weller M, Dichgans J, Petersen D: Voluntary facial palsy with a pontine lesion. J. Neurol. Neurosurg. Psychiatr. 61, 531-533, 1996
Kolbinger W., Trepel M, Beyer C, Pilgrim C, Reisert I: The influence of genetic sex on sexual differentiation of diencephalic dopaminergic neurons in vitro and in vivo. Brain Res. 554, 349-352, 1991

Übersichtsarbeiten / Reviews

Halms T, Strasser M, Hasan A, Rüther T, Trepel M, Raab S, Gertzen M.: Smoking and quality of life in lung cancer patients: systematic review. BMJ Support. Palliat. Care, in press
Dintner S, Schmutz M, Sommer S, Langer A, Hirschbühl K, Claus R, Schmid C, Trepel M, Märkl B: [NGS-based molecular genetics of leukemia-a powerful and decentralized approach][German]. Pathologie 44 (Suppl 3), 155-159, 2023
Trepel M, Gerl A, Rieger C: Die individualisierung Der CLL-Erstlinientherapie mit Ibrutinib. Lehre und Praxis, 2022
Hennigs JK, Matuszcak C, Trepel M, Körbelin J: Vascular Endothelial Cells: Heterogeneity and Targeting Approaches. Cells 10, 2712, 2021
Voigtländer M, Schneider-Merck T, Trepel M: Lapatinib. Recent Results Cancer Res. 211, 19-44, 2018
Fichtner M, Dreyling M, Binder M, Trepel M: The Role of B-Cell Antigen Receptors in Mantle Cell Lymphoma. J. Hematol. Oncol. 10, 164 (12 pages), 2017
Kubuschok B, Trepel M: Learning from the failures of drug discovery in B-cell non-Hodgkin lymphomas and perspectives for the future: chronic lymphocytic leukemia and diffuse large B-cell lymphoma as two ends of a spectrum in drug development. Expert Opin Drug Discov. 7, 733-745, 2017
Coßmann J, Trepel M: Klassifikation und aktuelle Therapiestrategien bei Non-Hodgkin-Lymphomen, Onkologische Pharmazie 19, 4-9, 2017
Körbelin J, Schwaninger M, Trepel M: Vascular-targeted recombinant adeno-associated viral vectors for the treatment of rare diseases. Rare Diseases 4, e1220470 (5 pages), 2016
Nolting M, Schneider-Merck T, Trepel M: Lapatinib. Recent Results Cancer Res. 201, 125-143, 2014
Schneider-Merck T, Trepel M: Lapatinib. Recent Results Cancer Res. 184, 45-59, 2010
Michelfelder S, Trepel M: Adeno-associated viral vectors and their redirection to cell-type specific receptors. Adv. Genet. 67, 29-60, 2009
Binder M, Trepel M: Drugs targeting integrins for cancer therapy. Exp. Opin. Drug Discovery 4, 229-241, 2009
Trepel M, Pasqualini R, Arap W: Screening phage-display peptide libraries for vascular targeted peptides, Meth. Enzymol. 445, 83-106, 2008
Kohlschütter J, Michelfelder S, Trepel M: Drug delivery in acute myeloid leukemia. Expert Opin. Drug Deliv. 5, 653-663, 2008
Arap W, Trepel M, Zetter BR, Pasqualini R: Innovations in prostate cancer research. Cancer Res. 68, 635-638, 2008
Trepel M, Arap W, Pasqualini R: In vivo phage display and vascular heterogeneity: implications for targeted medicine. Current Opinion in Chemical Biology 6, 399-404, 2002
Trepel M, Arap W, Pasqualini R: Exploring vascular heterogeneity for gene therapy targeting. Gene Therapy 7, 2059-2060, 2000

Buchkapitel

Waidhauser J, Trepel M: Blutbildveränderungen und hämatologische Onkologie. In: Hasan A (Hrsg.): Praxishandbuch Somatik und Psyche. Elsevier, pp 197-208, 2024
Seidel C, Nicolay NH, Trepel M, Jordan F, Barrantes-Freer A, Güresir E: ZNS-Tumoren. In: Honecker F, Claßen J, Preiß J, Dornoff W (Hrsg.): Taschenbuch Hämatologie und Onkologie. Zuckwerdt, pp 262-268, 2024
Seidel C, Kortmann RD, Trepel M, Jordan F, Meixensberger J: ZNS-Tumoren. In: Honecker F, Claßen J, Preiß J, Dornoff W (Hrsg.): Taschenbuch Hämatologie und Onkologie. Zuckwerdt, pp 252-258, 2022
Trepel M: Milztumoren. In: Dt. Krebsgesellschaft (Hrsg.): Gastrointestinale Tumoren. Elsevier, pp 443-447, 2018
Brandt A, Trepel M: Ätiologische und pathogenetische Grundlagen der Krebsentstehung. In: Koch U, Mehnert A (Hrsg.): Handbuch der Psychoonkologie , Hogrefe, pp 31-41, 2016
Müller F, Trepel M: Meningeosis neoplastica. In: Berger DP, Duyster J, Engelhardt M, Engelhardt R, Henß H, Mertelsmann R (Hrsg.): Das Rote Buch: Hämatologie und Internistische Onkologie, Ecomed, pp 1067-1071, 2013
Trepel M: Meningeosis neoplastica. In: Berger DP, Engelhardt M, Engelhardt R, Henß H, Mertelsmann R (Hrsg.): Das Rote Buch: Hämatologie und Internistische Onkologie, Ecomed, pp 1007-1011, 2010
Trepel M: Carcinomatous meningitis (leptomeningeal metastases). In: Berger DP, Engelhardt M, Henss H, Mertelsmann R (Eds.): Concise Manual of Hematology and Oncology, Springer, pp 764-767, 2008
Behringer D, Waller CF, Trepel M: Breast cancer. In: Berger DP, Engelhardt M, Henss H, Mertelsmann R (Eds.): Concise Manual of Hematology and Oncology, Springer, pp 597-610, 2008
Trepel M, Arap W, Pasqualini R: Selection, isolation, and identification of targeting peptides for ligand-directed gene delivery. In: Friedmann T, Rossi JJ (Eds.): DNA Delivery and Gene Transfer Vector Laboratory Manual, Cold Spring Harbor Press, pp 360-369, 2006

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